NAD⁺ Injection Before and Aftercare: What You Need to Know

An NAD⁺ injection is a quick treatment, but a little preparation can help make your appointment feel smoother and more comfortable.

NAD⁺, or nicotinamide adenine dinucleotide, is a coenzyme naturally found throughout the body. It plays an important role in cellular energy production and other essential processes. NAD⁺ injections are offered in wellness settings as a way to deliver additional NAD⁺ directly into the body, although research into their potential benefits is still developing.

To learn more about Beautyfluff’s NAD⁺ Weekly Injection, click here.

Because this is an injectable treatment, it is important to arrive well prepared, share your complete medical history, and keep an eye on the injection site afterward.

Here is what to know before and after your NAD⁺ injection at Beautyfluff.

Before Your NAD⁺ Injection

Tell Us About Your Health

Before treatment, let your Beautyfluff provider know about your medical history, medications, allergies, and any recent health changes.

Be sure to mention if you:

• Are pregnant, think you may be pregnant, or are breastfeeding

• Have active cancer

• Have liver or kidney disease

• Have a serious or uncontrolled medical condition

• Have an active infection, fever, or recent illness

• Have previously reacted to NAD⁺, niacinamide, an injection, or a compounded medication

• Have a history of fainting or becoming lightheaded around needles

Not every health condition leads to the same decision. Sharing these details simply helps your provider determine whether treatment is appropriate for you or whether it would be safer to wait.

Review Your Medications and Supplements

Give your provider a complete list of your prescription medications, over-the-counter products, vitamins, and supplements.

There are limited data on how injectable NAD⁺ may interact with other medications. An absence of well-documented interactions does not guarantee that none are possible.

Do not stop or change a prescribed medication on your own. Your provider can review everything you take and let you know whether any adjustments are necessary.

Hydrate Before Your Appointment

Drink water regularly during the day before and the day of your appointment, unless a medical professional has instructed you to limit fluids.

You do not need to drink an uncomfortable amount all at once. Simply arriving comfortably hydrated may help you feel better during and after the injection.

Eat a Light Meal or Snack

Have a light meal or snack approximately one to two hours before treatment, unless your provider gives you different instructions.

Arriving on an empty stomach may make nausea, dizziness, or lightheadedness more likely. Something simple and balanced is usually enough.

Avoid Alcohol, Caffeine, and Recreational Drugs

We recommend avoiding alcohol, caffeine, and recreational drugs for approximately 24 hours before treatment.

Alcohol may contribute to dehydration, while stimulants and other substances may affect how you feel during the appointment.

Let your provider know if you were unable to follow these instructions so they can determine whether treatment should proceed.

Contact Us if You Feel Unwell

If you develop a fever, infection, vomiting, diarrhea, or another recent illness, contact Beautyfluff before your appointment. It may be better to reschedule until you are feeling well. Your body already has enough to manage when it is recovering from an illness.

The Day of Your Appointment

Wear comfortable clothing that allows easy access to the planned injection site.

Depending on the prescribed formulation and route, your provider will choose an appropriate area for the injection. Avoid applying heavy lotion, body oil, or fragranced products over that area before arriving.

Before treatment begins, tell your provider about:

• Any new symptoms

• Medication changes

• A new allergy or reaction

• Pregnancy or breastfeeding

• Recent illness

• Any concern you have about the injection

If needles tend to make you nervous or lightheaded, please say so. This is very common, and knowing beforehand allows the Beautyfluff team to help you feel more comfortable.

What to Expect After an NAD⁺ Injection

Most people can return to light daily activities after their appointment.

Temporary effects may include:

• Redness, swelling, or soreness at the injection site

• Mild bruising

• Warmth or flushing

• Nausea

• Dizziness or lightheadedness

• Headache

• Fatigue

• Temporary changes in heart rate or blood pressure

These effects should generally remain mild and begin improving rather than becoming more intense.

Some people notice little immediate change after treatment, while others report temporary changes in energy or how they feel. Results and timing vary, and no specific response can be guaranteed.

NAD⁺ Injection Aftercare

Continue Hydrating

Continue drinking water normally throughout the day unless you have been advised to restrict fluids.

There is no need to force excessive amounts. Steady, comfortable hydration is enough.

Care for the Injection Site

A small amount of tenderness, redness, or bruising can be normal.

Keep the area clean and avoid rubbing, scratching, or massaging it. If needed, you may use a clean, wrapped cold compress for short periods. Do not place ice directly against your skin.

Contact Beautyfluff if the site becomes increasingly painful, hot, swollen, or red.

Take It Easy for the Rest of the Day

We recommend avoiding strenuous exercise for approximately 24 hours after treatment.

Gentle walking and normal daily activity are usually fine if you feel well. If you feel tired, dizzy, or mildly nauseated, give yourself permission to rest.

Avoid driving or operating equipment until lightheadedness has fully passed.

Avoid Alcohol for 24 Hours

Avoid alcohol for approximately 24 hours after your injection.

Alcohol may contribute to dehydration, flushing, dizziness, or nausea and can make it harder to tell how your body is responding to the treatment.

Eat Normally

Continue eating balanced meals and snacks throughout the day.

If you feel mildly nauseated, smaller and simpler meals may be more comfortable. Contact us if nausea is severe, continues worsening, or prevents you from eating or drinking.

When Should You Contact Beautyfluff?

Contact the clinic if you experience:

• Increasing pain, redness, warmth, or swelling at the injection site

• Pus, drainage, or red streaking

• Fever or chills

• Persistent dizziness or nausea

• A headache or fatigue that is severe or does not begin improving

• A spreading rash or hives

• Symptoms that continue worsening rather than settling

• Any reaction that feels unusual or concerning

It is always reasonable to ask when you are unsure. You do not need to wait until something becomes severe before reaching out.

When Should You Seek Emergency Care?

Call 911 or seek immediate medical attention for:

• Difficulty breathing

• Swelling of the face, lips, tongue, or throat

• Chest pain

• Fainting or loss of consciousness

• Severe weakness or confusion

• Widespread hives with difficulty breathing or swallowing

• Severe shaking, repeated vomiting, or another rapidly developing systemic reaction

These are not expected parts of recovery and should not be watched at home to see whether they improve.

Follow Your Personal Treatment Plan

NAD⁺ injections are compounded treatments, and the formulation, dosage, route, and schedule may vary.

Always follow the instructions provided directly by your provider. Do not change the dose or treatment frequency based on another person’s experience or information found online.

We may recommend a series of weekly injections followed by a personalized maintenance schedule. Your provider will determine what is appropriate based on your health, response, and wellness goals.

Conclusion

Preparing for an NAD⁺ injection is simple.

Arrive hydrated, eat a light meal, avoid alcohol and caffeine as instructed, and give your provider a complete picture of your health and medications.

After treatment, keep the injection site clean, continue drinking water, and take a short break from strenuous exercise and alcohol. Mild soreness, flushing, fatigue, or lightheadedness may occur, but symptoms should gradually improve.

At Beautyfluff, every NAD⁺ injection begins with thoughtful medical screening and an individualized treatment plan. We will explain what to expect, answer your questions, and make sure you know how to care for yourself afterward.

Book a consultation with Beautyfluff today to learn whether NAD⁺ injections may be an appropriate addition to your wellness plan.